New York City, USA – City Guide New York City is the largest city in the United States with around 20 million inhabitants and it is in the north-east of the United States of America on the coast of the Atlantic Ocean. The five boroughs which make up New York City are Manhattan, the Bronx, Brooklyn, Queens and Staten Island, the oldest and most influential being Manhattan. It is a cosmopolitan city which has become the backbone of the American economy, as well as a major player in international relations, being home to the United Nations. New York City is the most populated city in the United States and is known as the Big Apple or the city that never sleeps because of the constant buzz, both night and day. Find cheap flights to New York with eDreams and enjoy a break in the Big Apple.